Fish Oil of Sardinella Longiceps Inhibits Collagen Damage in Alveolarr Bone

Abstract

Fish oil contains eicosapentaenoic acid lemuru (EPA) and docohexaesonoic acid (DHA). Both n-3 polyunsaturated fatty acids, which are EPA and DHA has a function to reduce the occurrence of bone damage. The one that caused the bone damage is matrix metalloproteinase -1 (MMP-1), which is secreted by osteoclasts, osteoblasts and cytokines. MMP-1 is enzymes that break collagen. The purpose of this study was to analyze how the effect of fish oil S. longiceps on alveolar bone collagen tissue during odontogenesis. Thirty male Wistar rats aged 5 days, divided into 3 groups. The first group was the control group, rats not given any treatment. The second group, rats injected with LPS in the left maxillary molar region to cause periodontal infection. The third group, rats injected with LPS, such as group 2 and were given orally with fish oil doses 1ml/300-350 body weight / day. Rats were decapitated at the age of 13 days and 21 days. Collagen tissue damage was observed with knowing expression of matrix metalloproteinase -1 (MMP-1). The results of this study showed that rats that experienced periodontal infection significantly increased expression of MMP-1. Increased expression of MMP-1 resulted in damage to collagen. Groups of rats fed fish oil and injected with LPS had MMP-1 expression is lower than in the group of rats injected with LPS only. The conclusion of this study is that fish oil of S. longiceps may prevent the expression of MMP-1 that causes damage to collagen. Therefore it is said that fish oil prevents damage to the collagen in the alveolar bone.