| dc.description.abstract | The research on effect of propylene glycol in release rate of meloxicam from
Carbopol gel base in vitro has been carried out. Ultraviolet-visible
spectrophotometric analytical techniques were used for the meloxicam analysis.
The validated methods were employed for the determination of meloxicam in the
sample solutions taken from the receptor fluid. It was found that the release of
meloxicam through cellophane membrane was well described by the Higuchi
model. The research used concentrations of propylene glycol as much as 0, 20, 30,
and 40%. The results of stability test including organoleptic, pH, measuring of
viscosity, homogenity and release test used USP dissolution apparatus with
diffusion cells. The result showed that meloxicam gel contained propylene glycol
40 % was the release rate of 230,505 µg/ cm
2
/ menit
1/2 | en_US |
