OPTIMASI KOMPOSISI HIDROKSIPROPIL METILSELULOSA DAN CARBOPOL PADA TABLET METFORMIN HIDROKLORIDA SISTEM MENGAPUNG MENGGUNAKAN SIMPLEX LATTICE DESIGN

Abstract

Floating tablet for treatment of type 2 Non Insulin Dependent Diabetes Mellitus were prepared by mixing metformin hydrochloride with other excipients. The aim of this research was to study the profile of metformin hydrochloride release from sustained release tablet with a floating system. Floating tablets of metformin hydrochloride were prepared by using 2 different matrix of HPMC K100M and Carbopol 940. Citric acid and sodium bicarbonate was incorporated as a gas generating agent. The model formulation were prepared according to a simplex lattice design. Metformin hydrochloride floating tablets were made by direct compression method in 3 formulations based on the variation concentration of HPMC K100M and Carbopol 940. The concentration were 25% HPMC K100M and 0% Carbopol 940 (F1), 0% HPMC K100M and 25% Carbopol 940 (F2), 12,5% HPMC K100M and 12,5% Carbopol 940 (F3). Floating lag time, floating duration time and the drug release percentage at 1 h, 5 h and 10 h were selected as dependent variables. The responds were evaluated using simplex lattice design to get final optimized formulation. F1 had floating lag time above 600 seconds while F2 and F3 had floating lag time below 600 seconds. All formulation constantly floated on dissolution medium for more than 12 hours. The results of dissolution showed that the release profile of metformin hydrochloride following higuchian model (all formulation) that showed amount of metformin hydrochloride were released linear with square root of time. Mechanisms of metformin hydrochloride release were combination of erosion and diffusion. Mechanisms of metformin hydrochloride release more dominated by diffusion mechanism, the release is controlled by the ability of the drug diffuses through the matrix and the amount of drug released to the square root of time is linear.