SINTESIS 1-(2-KLOROBENZOILOKSIMETIL)-5-FLUOROURASIL SEBAGAI UPAYA PENGEMBANGAN OBAT ANTIKANKER

Abstract

5-fluorouracil is an antineoplastic agent that used for treating solid tumors such as breast, colorectal and gastric cancers. However, this product still show saveral side effects. A new compound of 5-fluorouracil derivative has been synthesized by two step reaction. The first step is the alkylation reaction between 5- fluorouracil with formaldehyde to produce 1-hydroxymethyl-5-fluorouracil. The second step is the esterification reaction between 1-hydroxymethyl-5-fluorouracil with 2-chlorobenzoylchloride to give the target compound, 1-(2- chlorobenzoyloxymethyl)-5-fluorouracil with 6 hours reaction time. This compound has been purified using Column Chromatography. And then, the isolate was characterized and identified using FTIR and 1H-NMR. The product is a yellowish white chrystalline and has melting range about 193-1940C. FTIR and 1H-NMR spectrum showed that 1-(2-chlorobenzoyloxymethyl)-5-fluorouracil was successfully synthesized with percent yield 1,984%.