SINTESIS 1-(3-NITROBENZOILOKSIMETIL)-5-FLUOROURASIL SEBAGAI UPAYA PENGEMBANGAN OBAT ANTIKANKER

Abstract

1- (3-nitrobenzoyloxymethyl)-5-fluorouracil as a derivative of 5-fluorouracil has been synthesized in a two step reaction. Subtitution of N1 of 5-fluorouracil with formaldehyde and followed by esterification reaction with 3-nitrobenzoylchlorida. Synthesis condition in term of time of reflux in the second step reaction has been optimized to produce the highest percent product. The product was purified used (Coloumb Chromatography) CC to obtain three groups of fraction. Based on the FTIR and 1H-NMR result, 1- (3-nitrobenzoyloxymethyl)-5-fluorouracil is expected to be present in the third group (fractionation 14-19).