PENGEMBANGAN SEDIAAN LEPAS LAMBAT SISTEM MATRIKS BERBASIS ETILSELULOSA – HIDROKSIPROPIL METILSELULOSA DENGAN TEKNIK DISPERSI SOLIDA

Abstract

The purpose of this research was to know the best formulation that can be form in development of sustained release dosage form based EC – HPMC matrix systems by solid dispersion technique. The result of this research expected can be used to next test according to in vivo method. Etilcellulose N22 is a hydrophobic polymer with high viscosity 20cps. With this high viscosity, EC can be used as a matrix in controlled release drug delivery systems. Addition HPMC as combination is to decrease excessive erosion, so this sustained release dosage form become stable in its release. Diclofenac sodium (ND) is a drug material that can used in sustained release by solid dispersion with EC (1:3) in formula F1, F2, F3. Addition of HPMC in each formula F1, F2 and F3 (5%, 10%, 15%) help matrices to controlling the release rates. Drug release profile of Diclofenac Sodium from matrix were evaluated in vitro by using dissolution apparatus type I with 50 rpm stirring rotation in base media of pH 6,8 for 8 hours. The sample solutions were analyzed for Diclofenac Sodium by UV absorbance at 281 nm using Spectrophotometer UV-Vis U1800. The result showed that the release of Diclofenac Sodium from EC matrix without combination with HPMC was able to perform an ideal formulation of sustained release dosage form. There was no significant difference in drug release between the hydrophyllic matrices when the HPMC concentration was modified in low percentage (5%). The best-fit release kinetics with the highest correlation coefficient was achieved with the Higuchi method, followed by the first-order plot and the zero-order equations, respectively, over 8 hour.