PERBANDINGAN KARAKTERISTIK FISIK DAN PELEPASAN MELOKSIKAM DARI BASIS HIDROKSIPROPILMETIL SELULOSA, CARBOPOL, DAN NATRIUM KARBOKSIMETIL SELULOSA
Abstract
The present research has been undertaken with the aim to develop a topical gel
formulation of Meloxicam using different gelling agent Carbopol, Na CMC, and
HPMC, which would avoid to side effects with oral administration. They were
evaluated for physicochemical properties such as organoleptic, viscosity, pH,
Spreadability, homogeneity and, in vitro drug release. The in vitro drug release rate
of gel was evaluated using apparatus disolution containing cellophane membrane
with phosphate buffer saline pH 7,4 ± 0,05 as the receptor medium. Studies showed
that drug release was decrease with viscosity increases.
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- UT-Faculty of Pharmacy [1466]