| dc.description.abstract | Piroxicam is one of non steroid anti drug inflamatory (NSAID) with structure of
oksikam. This drug commonly used for rheumatoid arthritis and osteoarthritis. For
local symptomatic pain and inflammation relief, 0,5% piroxicam used topically as gel
or cream dosage form with various excipients. The aim of this research was to study
the profile of piroxicam release from sustained release gel with permeation enhancer.
Piroxicam gel were prepared by using 2 permeation enhancer of propylene glycol
and glycerine. The model formulation were prepared according to a simplex lattice
design.In this study,three piroxicam gels were prepared using Carbopol as gelling
agent with variation concentration of propylene glycol and glycerin. The
concentration were 15% propylene glycol and 0% glycerine (F1), 0% propylene
glycol and 15% glycerine (F2), 7,5% propylene glycol and 7,5% glycerin (F3).
Viscosity, pH, and diffusion rate of drug were selected as dependent variabels. The
responds were evaluated using simplex lattice design to get final optimized
formulation. F1 had diffusion rate 0,2343 µg/cm
2
.menit, F2 had diffusion rate 0,1021
µg/cm
2
.menit and F3 had diffusion rate 0,4401 µg/cm
2
.menit. Drug diffusion rate
testing was held for 8 hours using Franz Diffusion Cell at 37
o
C±0,5
C. Propylene
glycol and glycerine possibly infiltrates the outermost layer of the intercellular
spaces of the stratum corneum and because most of the water accumulates within the
corneocytes, it seems likely that propylene glycol and glycerine withdraws water from
the cells due to its hygroscopic nature, causing skin hydration and thus enhances
drug penetration. Addition of propylene and glycerine can improve condensation
medicine from effect of cosolvent so that both the materials can improving diffusion.
Key word: Gel, piroxicam, propylene glycol, glycerine, simplex lattice design | en_US |
