Optimasi Komposisi Hidroksipropil Metilselulosa, Natrium Alginat Dan Natrium Karboksimetilselulosa Pada Tablet Propranolol Hidroklorida Sistem Mengapung Dan Lekat Mukosa

Abstract

A combination floating and mucoadhesive drug delivery system of propranolol hydrochloride tablet has been developed to increase its bioavailability by increasing the retention time of the drug in the gastrointestinal tract. The aim of this study was to formulated, optimized, and obtained the optimal composition of Hidroxypropyl Methylcellulose (HPMC), Sodium Alginate and Sodium Carboxymethylcellulose (CMC Na) in control release tablets of Propranolol Hydrochloride combination floating and mucoadhesive system. The tablet were prepared by direct compression technique. Optimization was carried out using simplex lattice desaign (SLD). Tablets were evaluated for in-vitro buoyancy, swelling index and mucoadhesive studies. Invitro buoyancy and mucoadhesive is used as a parameter optimization on SLD model equation. HPMC, Sodium Alginat and CMC Na are dominant factor in increasing invitro buoyancy and mucoadhesive. Optimum proportion of HPMC (83,673), Sodium Alginat (46,327), CMC Na (30) are obtained based on the superimposed countour plot. Key word: Floating-mucoadhesive, Propranolol HCl, HPMC, Sodium Alginat and