PENGARUH EKSTRAK TEMPE TERHADAP APOPTOSIS DAN PROLIFERASI SEL KANKER PAYUDARA PADA TIKUS PUTIH GALUR WISTAR YANG DIINDUKSI DMBA
Abstract
Cancer is the leading cause of death worldwide and breast cancer is
second rank of largest cancer in the world. Breast cancer ranked first on the
patients hospitalization throughout hospital in Indonesia and ranked second in
East Java. Breast cancer require high costs, for both preventions and treatments..
Tempe contain isoflavones that suspected be able to induce apoptosis and inhibit
proliferation of breast cancer cells. Therefore this research needs to be done to
find out the effect of tempe as breast cancer prevention through increasing
apoptosis and decreasing proliferation of breast cancer cells. The objective of this
research is to examine and analyze the effect of tempe extract to increasing
apoptosis and decreasing proliferation of breast cancer cells in DMBA-induced
rats strain Wistar and to know the effective doses of tempe extract. This research
is a true experimental design study using randomized posttest control group
design with completely randomized design. Research done to Rattus norvegicus
strain Wistar induced DMBA and given tempe extracts according to the oral dose
per group. The number of apoptosis and proliferation of calculated and analyzed
with MANOVA test (Multivariate Analysis of Variance) and Simple Linear
Regression test. The results is there are significant differences effect of giving
tempe extract against apoptosis and proliferation of breast cancer cells in all dose
groups. Dose of 20 mg/kgBW has a significant differences with the other
treatment group. The results showed the most effective dose is the dose of 20
mg/kgBW.
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- UT-Faculty of Public Health [2275]