| dc.description.abstract | Introduction: A wound is a disruption of the cellular, anatomical and functional
continuity of a tissue caused by sharp or blunt trauma and others. Flavonoids which
have anti-inflammatory, antibacterial and antioxidant properties have the potential
to be wound healing agents. But, no systematic review and meta-analysis exists for
evidence-based medicine.
Objective: To determine the effect of topical administration of alcohol extracts of
natural ingredients containing flavonoids in improving histopathology,
epithelialization period and contraction of sharp wounds.
Method: Systematic review and Meta-analysis based on Preferred Reporting Items
for Systematic Reviews and Meta-Analyses (PRISMA). Studies were searched
through four databases. Studies were selected based on eligibility criteria and
quality assessment using Systematic Review Centre for Laboratory animal
Effect size use Mean Difference (MD) with 95% Confidence Interval (CI). Random
or fixed effect models were used based on the level of heterogeneity, and were
considered significant if the p value is <0.05.
Result: Researchers obtained 569 studies which were selected into 6 studies. Five
of the six studies concluded that flavonoid significantly improve the histopathology
of wounds. In the meta-analysis, the the epithelization period is significantly faster
(MD= -3,63, 95% CI [-4,32; -2,95], p<0,00001, I2= 73%). The percentage of
wound contraction was also significantly greater on days 3 (MD= 2,37, 95% CI
[1,48; 3,26], p<0,00001, I2= 10%), 6 (MD= 11.11, 95% CI [8,01; 14,22],
p<0,00001, I2= 88%), 9 (MD= 19,12, 95% CI [12,72; 25,52], p<0,00001, I2=
97%), 12 (MD= 15,99, 95% CI [9,60; 22,39], p<0,00001, I2= 99%), 15 (MD=
12,15, 95% CI [6,47; 17,82], p<0,0001, I2= 0%), 18 (MD= 13,13, 95% CI [4,70;
21,56], p= 0,002, I2= 100%).
Conclusion: The administration of alcohol extracts of natural ingredients
containing flavonoids has been proven to improve the histopathology of sharp
wounds, increase the epithelization period and wound contraction. | en_US |
