The Effects of Carica papaya L. Juice on Plasma Aspartate Transaminase/Alanine Transaminase Level and Liver Histopathology in Paracetamol–Induced Mice

Abstract

Liver is one of the primary and largest metabolic organs in the body. The function of the liver can be disturbed and damaged by paracetamol and liver damage can be prevented with papaya (Carica papaya L.). The purpose of this study was to know the effects of C. papaya juice on plasma AST/ALT level and liver histopathology in paracetamol-induced mice. Amount 25 Balb–C mice (Mus musculus) were divided into five treatment groups, there were normal, negative control, papaya juice dose (200, 400, 600) mg kg groups. The treatment was carried out for 7 d and then all mice (without normal groups) was induced by paracetamol. On the 8 –1 –1 bw d, blood was collected and all mice were sacrificed. The materials used in this study include C. papaya juice, CMC Na, paracetamol, AST and ALT reagents, Hematoxylin-Eosin and used Experimental Laboratory methods. One Way ANOVA and Kruskal Wallis with a confidence level of 95 % and followed by a post hoc test (LSD) to determine differences between groups. Showed that pretreatment with papaya juice could prevent liver damage and inhibit the increase of plasma AST/ALT level and papaya juice dose 600 mg kg th had significant effects on plasma AST/ALT level and liver histopathology in paracetamol-induced mice. Carica papaya L. juice can be used as a hepatoprotective agent.