Please use this identifier to cite or link to this item: https://repository.unej.ac.id/xmlui/handle/123456789/101056
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dc.contributor.authorCHRISTIANTY, Fransiska Maria-
dc.contributor.authorDIANASARI, Dewi-
dc.contributor.authorHOLIDAH, Diana-
dc.contributor.authorBASYRAHIL, Nargiss Lukman Hakim Salim-
dc.contributor.authorRIZKI, Putri Efina Tsamrotul-
dc.contributor.authorSAPUTRI, Laili Nurul Didik-
dc.contributor.authorJANI, Yahya-
dc.contributor.authorZALIZAR, Lili-
dc.date.accessioned2020-09-30T03:18:17Z-
dc.date.available2020-09-30T03:18:17Z-
dc.date.issued2020-05-01-
dc.identifier.urihttp://repository.unej.ac.id/handle/123456789/101056-
dc.description.abstractLiver is one of the primary and largest metabolic organs in the body. The function of the liver can be disturbed and damaged by paracetamol and liver damage can be prevented with papaya (Carica papaya L.). The purpose of this study was to know the effects of C. papaya juice on plasma AST/ALT level and liver histopathology in paracetamol-induced mice. Amount 25 Balb–C mice (Mus musculus) were divided into five treatment groups, there were normal, negative control, papaya juice dose (200, 400, 600) mg kg groups. The treatment was carried out for 7 d and then all mice (without normal groups) was induced by paracetamol. On the 8 –1 –1 bw d, blood was collected and all mice were sacrificed. The materials used in this study include C. papaya juice, CMC Na, paracetamol, AST and ALT reagents, Hematoxylin-Eosin and used Experimental Laboratory methods. One Way ANOVA and Kruskal Wallis with a confidence level of 95 % and followed by a post hoc test (LSD) to determine differences between groups. Showed that pretreatment with papaya juice could prevent liver damage and inhibit the increase of plasma AST/ALT level and papaya juice dose 600 mg kg th had significant effects on plasma AST/ALT level and liver histopathology in paracetamol-induced mice. Carica papaya L. juice can be used as a hepatoprotective agent.en_US
dc.language.isoenen_US
dc.publisherAnnals of Tropical Medicine & Public Health, May 2020 Vol. 23 Issue 8en_US
dc.subjectAdvantage papaya for healthen_US
dc.subjectAST/ALTen_US
dc.subjecthepatoprotective agenten_US
dc.subjectin vivoen_US
dc.subjectmanja roenigk scoreen_US
dc.titleThe Effects of Carica papaya L. Juice on Plasma Aspartate Transaminase/Alanine Transaminase Level and Liver Histopathology in Paracetamol–Induced Miceen_US
dc.typeArticleen_US
dc.identifier.kodeprodikodeprodi2210101#Farmasi-
dc.identifier.nidnNIDN0006048405-
dc.identifier.nidnNIDN0008128701-
dc.identifier.nidnNIDN0021127801-
Appears in Collections:LSP-Jurnal Ilmiah Dosen



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