Optimasi Dosis Terapi Kanker Paru-Paru Menggunakan Program Phits V 3.35 dengan Metode Boron-Neutron Capture Therapy

Abstract

Lung cancer remains one of the leading causes of cancer-related mortality worldwide, particularly in advanced stages. Boron Neutron Capture Therapy (BNCT) is a promising alternative treatment due to its ability to deliver high-dose radiation selectively to cancer cells. This study aims to determine the optimal boron concentration, estimate the appropriate irradiation time, and compare the efficiency of Posterior Anterior (PA) and Right Lateral (RLAT) beam directions in lung tissue. The simulation was conducted using clinical data from a 66-year-old male patient with a tumor located in the upper right lung. The target volumes included a Gross Tumor Volume (GTV) of 4.17 cm³, Clinical Target Volume (CTV) of 7.81 cm³, and Planning Target Volume (PTV) of 12.93 cm³. Dose constraints for organs at risk, such as the spinal cord, heart, and healthy lung tissue, were also considered. The results indicate that PHITS is capable of accurately estimating dose distribution within the tumor while maintaining radiation exposure to surrounding healthy tissues within safe limits. A boron concentration of 120 μg/g was found to be the most optimal, as it achieved the therapeutic dose with a shorter irradiation time compared to 80 μg/g and 100 μg/g, although both lower concentrations still met safety limits but required longer irradiation times. Furthermore, the Posterior Anterior direction was more efficient than the Right Lateral direction, providing shorter irradiation times and a safer dose distribution to healthy tissues.