Enhancement of IL23-Independendent IL17 Level on Intraperitoneal Injection of Candida albicans Cell Wall in Wistar Male Rat

Abstract

IL17 is one of the most interesting cytokines studied recently because that cytokine involve on pathogenesis of wide range diseases. Production of this cytokine involve IL6, IL1β and IL23. Many evidence proved that there is an elevation of IL17 in peripheral blood in C. albicans infection. The aims of this study was to analyzed the effect of C.albicans cell wall injection intraperitoneally in level of IL17 and IL23. C.albicans cell wall isolated form C. albicans ATCC 10231 were administered intraperitoneally for 5 days in two series with 14 days interval on 3 group of wistar male rat. The doses of C. albicans cell wall were 0.8mg/kg bw/d, 1.6 and 3.2mg/kgbw/d. Control group were injected by aquadest pro injection. IL17 and IL23 blood level analyzed by ELISA technique 24 hours after last injection. There was a significant increase in the level of IL17 but not accompanied by IL23. The elevation of IL23-independet IL17 in the exposure of C. albicans cell wall supported the hypothesis that as respond of pathogen, elevation of IL 17 not necessarily preceded elevation of IL23. This hypothesis implicated that the IL23-independent IL17 likely have more protective effect than pathogenic effect as such in autoimmune diseases.