| dc.description.abstract | One of the main factors causing stroke is atherosclerosis i.e. narrowing of the arteries due to deposition of
cholesterol and other substances or substances called atherosclerotic plaques. Atherosclerosis can be caused
also by infection from odontogen and its supportingtissue. P. gingivalis bacteria are often associated with a
risk factor for atherosclerosis. Bacteria along with its products in the form of exotoxin and endotoxin enter
into the systemic blood circulation and stimulate blood clot to the brain, causing a stroke. Infection in the
tooth root and its supportingtissue involves a lot of bacteria and microorganisms, infection is very close to
the blood vessels, toxins, free radicals, bacteria themself, a cytokine releasedtogether with inflammation
entering into the bloodstream and can cause inflammation of plaque in blood vessels, plaques block blood
vessels to the brain causing a stroke. Purpose: Analysis of the mechanism of stroke caused by infection
odontogen and its supportingtissue. Review: Bacterial products in the form of exotoxin and endotoxin, free
radicals, cytokines enter into the systemic circulation and stimulates the occurrence of thrombogenesis by
inducing platelet aggregation and increasing blood clotting factors. Bacteria may also enter into
endothelium and stimulate inflammatory processes in the arteries, inflammatory stimulation secretes a
specific enzyme i.e. metalloproteinase which can cause plaque rupture and be a risk factor for stroke.
Conclusion: There is relationship between oral cavity infection and stroke. Poor oral health becomes one of
risk factor for atherosclerosis. Atherosclerosis is one of the main factors triggering the occurrence of stroke.
Some pathogenic bacteria causing chronic inflammation have been considered as the basic mechanisms of
atherosclerosis, inflammation plays an important role in the development of atherosclerosis. | en_US |
