SINTESIS 1-(4-TRIFLUOROMETILBENZOILOKSIMETIL)-5FLUOROURASIL SEBAGAI UPAYA PENGEMBANGAN OBAT ANTIKANKER

Abstract

ABSTRACT

5-fluorouracil is an antimetabolite class of anticancer agents that work induces apoptosis by inhibiting thymidilic acid biosynthesis. A novel 5-fluorouracil derivatives, 1-(4-trifluoromethylbenzoyloxymethyl)-5-fluorouracil were synthesized by two steps reaction. The first step is alkylation reaction between 5-fluorouracil, formaldehyde and aquadest to produce 1-hidroxymethyl-5-fluorouracil. The second step is benzoylation reaction between 1-hidroxymethyl-5-fluorouracil and 4trifluoromethylbenzoylchloride for 11 hours to produce

the target compound. Target compound purified by column chromatography. Purified compound characterized and identified by 1 HNMR and FTIR KBr. Product compound form white needles crystal with melting range 172-174 o C. Spectra of 1 HNMR and FTIR KBr showed that pure 1-(4-trifluoromethylbenzoyloxymethyl)-5-fluorouracil was successfully synthesized.