| dc.description.abstract | Chronic inflammation and neuropathic pain are classified into chronic pain. Until now there are so many drugs
that have been used for chronic pain but the effectiveness still lower. One of the plants that are commonly used for
medicine in Indonesia is red ginger (Zingiber officinale var. rubrum). This study was aimed to analyze the component of
red ginger oil and proved its antihyperalgesia potency in chronic pain using two models, inflammatory pain and
neuropathy pain. Forty-eight mice were divided into 2 groups i.e. inflammatory and neuropathy. Each group was divided
into 6 subgroups (@4 mice) i.e. for inflammatory model (sham, negative control, red ginger oil doses 100, 200, 400 and
600 mg/kg) and for neuropathy model (sham, negative control, red ginger oil doses 100, 200, 400 and 600 mg/kg).
Inflammatory model was induced using Completed Freud's Adjuvant (CFA) 40 l intraplantar. Neuropathy model was
induced using Partial Sciatic Nerve Ligation (PSNL). At day-7, all groups were given orally treatment, once daily for
seven days. The latency time toward thermal stimulus and plantar thickness were measured at day 0,1,3,5,7,8,10,12 and
14 after induction. Quality of red ginger oil was standardized by Indonesia standard (SNI 06-1312-1998). The red ginger
oil compound was identified by GC/MS. The result showed that red ginger oil was qualified based on SNI 06-13121998.
Red
ginger
oil
200
mg/kgBW
and
400mg/kgBW
administration
in
mice
gave
the
best
result
in
prolong
the
latency
time
toward
thermal
stimulus
using
hot
plate
and
significantly
different
with
inflammatory
and
neuropathy
group.
From
GC/MS
analysis, camphene was known as the highest compound of red ginger oil that might be important for its
antihyperalgesia effect. The conclusion of this study that red ginger oil have antihyperalgesia activity in mice with
chronic pain and could be developed further to be antihyperalgesia. | en_US |
