45 kDa Fimbria Protein of Proteus mirabilis as Hemagglutinin and Adhesion Protein

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dc.contributor.author Mufida, Diana Chusna
dc.contributor.author Suswati, Enny
dc.contributor.author Wahyudi, Septa Surya
dc.contributor.author Kurniawan, Agung
dc.date.accessioned 2019-01-17T02:16:36Z
dc.date.available 2019-01-17T02:16:36Z
dc.date.issued 2019-01-17
dc.identifier.issn 0303-7932
dc.identifier.uri http://repository.unej.ac.id/handle/123456789/89424
dc.description Folia Medica Indonesia, vol 46 no. 2 April-June 2010; 88-94 en_US
dc.description.abstract Proteus mirabilis is opportunistic and nosocomial pathogen that usually found in clinical specimen from patients with catheter. The pathogenic mechanism of the bacteria are not fully elucidated especially its potential activity of the protein as hemagglutinin and adhesion molecule. The aim of this study is to evaluate the role of 45 kDa fimbria protein from P. mirabilis. After identification, bacterial isolate of fimbria fraction 12,5 % SDS-PAGE were used to isolate fimbria protein followed by hemagglutinin test and in vitro adhesion test. The study showed that the 45 kDa fimbria protein of P mirabilis was a hemagglutinin protein that could agglutinate mice erythrocytes, rabbit erythrocytes, and human group O erythrocytes. Hemaglutination test were negative on erythrocytes human blood group A,B, and AB. The 45 kDa fimbriae protein was also adhesion protein showed by its activity to adherence to rabbit vesica urinaria epithel receptor. The increase dose of 45 kDa fimbriae protein will decrease the amount of P mirabilis bacteria to adherence to rabbit vesica urinaria epithel (p< 0,05 ). en_US
dc.language.iso en en_US
dc.subject Proteus mirabilis en_US
dc.subject fimbriae en_US
dc.subject hemagglutinin protein en_US
dc.subject adhesion protein en_US
dc.title 45 kDa Fimbria Protein of Proteus mirabilis as Hemagglutinin and Adhesion Protein en_US
dc.type Article en_US

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