| dc.description.abstract | Objective: To investigate whether total cholesterol and C-reactive protein levels could be use as a prognostic factor for
outcome in patients with urosepsis. Material & Methods: An analytic observational study using 30 patients assigned for
total cholesterol and CRP level at the day of admission, three days later, and on the last day of sepsis or on the dead day. All
subjects were managed according to standard urosepsis therapy. At the 14 ,h day of treatment, patients were evaluated with a
clinical severity score. Then we classified the outcome as improve/good condition, worse, and died. The variables were
statistically tested using Spearman's rho test with software SPSS 20. P < 0.05 was consider significant. Result: From 30
subjects with urosepsis, we found 15 patients in septic condition, 14 patients had severe sepsis and one patient had septic
shock. The mean of total cholesterol level in patient with died and worse was lower than that in patient with good outcome.
Day 1 (63.25 mg/dl and 101.38 mgldl vs 119.5 mg/dl), day 3 (56.0 mg/dl and 93.6 mg/dl vs 128.6 mg/dl) and last day/died
day (51. 0 mg/dl and 82.25 mg/dl vs 154.8 mg/dl). The mean of CRP level in patient with died and worse was higher than that
in patient with good outcome. Day 1 (177.18 mg/! and 146. 74 mg/! vs 88.1 mg/!), day 3 (127.1 mg/! and 148.8 mg/! vs 56.2
mg/!) and last day/died day (141.88 mg/! and 88.71 mg/! vs 31.58 mg/!). These were statistically significant between total
cholesterol and CRP levels in determining the outcome of urosepsis patient. Day 1 (p 0.000 vs 0.011), day 3 (p 0.000 vs
0. 002), and last day/died day (p 0. 000 vs 0. 000). The coefficient correlation total cholesterol was better than CRP in day 1
(rho -0.633 vs 0.459), day 3 (rho -0. 755 vs 0.543), and last day/died day (rho -0.874 vs 0.686). Conclusion: Low total
cholesterol and high C-reactive protein levels can be used as poor prognostic in urosepsis patients. Total cholesterol level
was better than CRP as a prognostic marker. | en_US |
