| dc.contributor.author | Zulharini, Meirizky | |
| dc.contributor.author | Sutejo, Ika Rahmawati | |
| dc.contributor.author | Fadliyah, Hilyatul | |
| dc.contributor.author | Jenie, Riris Istighfari | |
| dc.date.accessioned | 2018-09-27T04:06:56Z | |
| dc.date.available | 2018-09-27T04:06:56Z | |
| dc.date.issued | 2018-09-27 | |
| dc.identifier.issn | 2088-0197 | |
| dc.identifier.uri | http://repository.unej.ac.id/handle/123456789/87489 | |
| dc.description | Indonesian Journal of Cancer Chemoprevention, 2017, 8(3): 94-100 | en_US |
| dc.description.abstract | Breast cancer is one type of cancer with a high mortality rate due to its metastatic
property. Red betel leaves (Piper crocatum Ruiz dan Pav) has been known as herbal
medicine containing biophenolic, such as apigenin and luteolin derivatives which has
cytotoxic activity toward cancer cells. This study is intended to explore the inhibitory
effect of Piper crocatum leaves methanolic extract (PCM) on cell proliferation and
migration by using 4T1 cells as model of metastatic breast cancer. By using MTT assay,
PCM performed cytotoxic activity in a dose dependent manner with IC
50
value of 120
μg/mL. Wound healing assay revealed that migration inhibitory activity of PCM on 4T1
cells at the concentration of 30 µg/mL. In conclusion, PCM perform cytotoxic effect
and antimigration activity toward metastatic breast cancer cells. | en_US |
| dc.language.iso | en | en_US |
| dc.subject | breast cancer cells | en_US |
| dc.subject | Piper crocatum Ruiz & Pav | en_US |
| dc.subject | cytotoxic | en_US |
| dc.subject | cell mgration | en_US |
| dc.title | Methanolic Extract of Red Betel Leaves (Piper crocatum Ruiz & Pav) Perform Cytotoxic Effect and Antimigration Activity toward Metastatic Breast Cancer | en_US |
| dc.type | Article | en_US |
