| dc.description.abstract | Pharmaceutical cocrystal is one of solid-state modification for drug substance,
mainly for
solubility
improvement.
Traditionally,
cocrystal
can be
prepared
by
solvent
evaporation
method, grinding,
and slurry
method, but,
every
method has limitation
for
certain
condition. The
current
trend for
cocrystal
formation
uses the sophisticated method such
as hot-melt extrusion
method, spray
drying
method, supercritical fluid technology
and the
newest,
and laser irradiation
method. Development
of new
method is not
only
to overcome
the limitation
of traditional cocrystallization
methods but
also
to generate a simpler step and continuous process for
the production
of cocrystal product. This article gives a brief explanation of each method that can be used to generate pharmaceutical cocrystals. | en_US |
