| dc.description.abstract | Introduction: Diabetic wounds or ulcers happened in Indonesia’s hospitalized diabetes
patients range from 17.3 to 32.9%. The high cost of treatment, the high risk of amputation and
the difficulty of handling diabetic wounds, make it necessary to look for alternative medicine
derived from plants e.g. Merremia mammosa (Mm). This study aimed to analyze the potential
dose of the water fraction of Mm (Lour.) extract on diabetic wound healing enhancement.
Method: This study used fifty-seven male wistar rats that were made diabetic by
intraperitoneal injection of 40 mg/kg body weight streptozotocin. Rats divided into six groups
equally, which consist of positive control (gentamicin 0.1%), negative control (aquadest) and
water fraction of Mm (Lour.) extract dose 12.5 mg, 25 mg, 50 mg and 100 mg. Wound was
made by Morton method and treatment applied on the wound every other day for 21 days.
Wound healing process were observed by percent wound healing and histopathological
changings on day 0, 3, 10 and 25, representing each healing phase.
Results: The percentage of reduction in wound size comparison at day 10 showed no
significant different when compared with positive control started from dose 50 mg. This result
is consistent with the histopathological changings parameter (angiogenesis, macrophage,
fibroblast and collagen density).
Conclusion: Water fraction of Mm (Lour.) extract was dose-dependently enhanced the
process of wound healing in diabetic rat model and the most effective dose was 100 mg, which
looks similar with positive control. Therefore, it is potential to be developed further as a topical
drug. | en_US |
