| dc.description.abstract | Meloxicam is one of the oxicam anti-inflammatory drugs
that are effective to relieve toothaches, arthritis, dysmenorrhea,
and fever. Meloxicam in this study was milled with High Energy
Milling (HEM) method to obtain nano size and then direct
compression method was used to produce Orally Disintegrating
Tablet (ODT). ODT is designed to be rapidly dissolved on the
tongue within a minute. It can be administered without water or
chewing and may improve the bioavailability and effectiveness of
the drug, and increase the patient’s adherence. The present
study aimed to understand the effects of Ac-Di-Sol and Kollidon
CL as superdisintegrants, that were used separately or in
combination, on the characteristics of nanoparticles meloxicam
ODT. It was also to obtain the best proportion of combination
between Ac-Di-Sol and Kollidon CL that can produce the optimum
formula of meloxicam ODT. The effects of single or combined
superdisintegrants were evaluated using Simplex Lattice Design
(SLD). Ac-Di-Sol (X
1
) and Kollidon CL (X
) were independent
variables, while dependent variables were friability (Y
2
),
disintegrating time (Y
2
), wetting time (Y
), and percent
meloxicam release after 60 seconds (Y
4
3
). Optimization of five
nanoparticle meloxicam ODT formulas was conducted using
Design Expert 7.1.5. The combination of Ac-Di-Sol 4.05mg (X
)
and Kollidon CL 10.95mg (X
) in 150mg nanoparticles meloxicam
ODT could produce optimal ODT characteristics. After
verification, there was no difference between predicted value and
observed value with p-value > 0.05. | en_US |
