| dc.description.abstract | Although malaria had ever been virtually eradicated from Indonesia but currently malaria is recognized as a
serious re-emerging threat to public health. This disease is caused by malaria parasite which is transmitted to
human host by Anopheles mosquitoes as main vector. It has been widely observed that saliva of mosquito that
transmits disease contains several factors that could enhance pathogen infection. Therefore, it should be possible
to control pathogen transmission by vaccinating the host against the molecule(s) in saliva that potentiate the
infection. However, immunogenic specific component in mosquitoes vectors of Malaria has not yet been
identified so far. The objective of this study are to analyze protein profile of SDS-PAGE and to know the
immunogity the protein extract of salivary gland from potential vector of Malaria i.e. An. Aconitus. We used
immunogenic reaction between salivary gland extract of these vectors against pool of human sera which were
collected from endemic area. The reaction conducted by the dot-blot analyze. SDS-PAGE studies showed 15
major polypeptide bands of 284, 100, 84, 75, 66, 57, 53, 48, 45, 38, 33, 29, 15, 14, and 11 kDa. The dot-blot
studies showed that the protein extract of salivary gland from An. aconitus are immunogenic. | en_US |
