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dc.contributor.authorArimura, Emi 
dc.contributor.authorMarchianti, Ancah Caesarina Novi 
dc.contributor.authorPulong, Wijang Pralampita
dc.contributor.authorNakakuma, Miwa
dc.contributor.authorAbe, Masaharu
dc.contributor.authorUshikai, Miharu
dc.contributor.authorHoriuchi, Masahisa
dc.date.accessioned2016-06-07T01:02:38Z
dc.date.available2016-06-07T01:02:38Z
dc.date.issued2016-06-07
dc.identifier.issn14366207
dc.identifier.issn14366215
dc.identifier.urihttp://repository.unej.ac.id/handle/123456789/74528
dc.descriptionhttp://link.springer.com/article/10.1007/s00394-015-1075-y European Journal of Nutrition Vol. 34/No.10/2015en_US
dc.description.abstractPurpose: We previously showed the deleterious effects of increased dietary protein on renal manifestations and glucose metabolism in leptin receptor-deficient (db) mice. Here, we further examined its effects on glucose metabolism, including urinary C-peptide. We also orally administered mixtures corresponding to low- or high-protein diets to diabetic mice. Methods: In diet experiments, under pair-feeding (equivalent energy and fat) conditions using a metabolic cage, mice were fed diets with different protein content (L diet: 12 % protein, 71 % carbohydrate, 17 % fat; H diet: 24 % protein, 59 % carbohydrate, 17 % fat) for 15 days. In oral administration experiments, the respective mixtures (L mixture: 12 % proline, 71 % maltose or starch, 17 % linoleic acid; H mixture: 24 % proline, 59 % maltose or starch, 17 % linoleic acid) were supplied to mice. Biochemical parameters related to glucose metabolism were measured. Results: The db–H diet mice showed significantly higher water intake, urinary volume, and glucose levels than db–L diet mice but similar levels of excreted urinary C-peptide. In contrast, control-H diet mice showed significantly higher C-peptide excretion than control-L diet mice. Both types of mice fed H diet excreted high levels of urinary albumin. When maltose mixtures were administered, db–L mixture mice showed significantly higher blood glucose after 30 min than db–H mixture mice. However, db mice administered starch–H mixture showed significantly higher blood glucose 120–300 min post-administration than db–L mixture mice, although both groups exhibited similar insulin levels. Conclusions: High-protein, low-carbohydrate diets deteriorated diabetic conditions and were associated with insufficient insulin secretion in db mice. Our findings may have implications for dietary management of diabetic symptoms in human patients.en_US
dc.description.sponsorshipSpringer Berlin Heidelbergen_US
dc.language.isoenen_US
dc.subjectHigh-proteinen_US
dc.subjectdiet- Insulinen_US
dc.subjectsecretion- db mice- Oral administration- Urinary C-peptideen_US
dc.titleDeteriorated glucose metabolism with a high-protein, low-carbohydrate diet in db mice, an animal model of type 2 diabetes, might be caused by insufficient insulin secretionen_US
dc.typeArticleen_US


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