• Login
    View Item 
    •   Home
    • LECTURER SCIENTIFIC PUBLICATION (Publikasi Ilmiah)
    • Karya Deposit Ilmiah
    • Fakultas Kedokteran Gigi
    • View Item
    •   Home
    • LECTURER SCIENTIFIC PUBLICATION (Publikasi Ilmiah)
    • Karya Deposit Ilmiah
    • Fakultas Kedokteran Gigi
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    The Effect of Different Orthodontic Force on MMP 9 Expression in A Rat Diabetic Model

    Thumbnail
    View/Open
    JTROLIS Vol. 4 No. 2 2014.pdf (4.480Mb)
    Date
    2015-07-07
    Author
    Hafiedz Maulana
    Nuzulul Hikmah
    Amandia Dewi Permana Shita
    Nur Permatasari
    Sri Widyarti
    Metadata
    Show full item record
    Abstract
    Orthodontic forces produce alveolar bone and periodontal ligament remodeling that cause tooth movement. Diabetes can increase tissue damage and, therefore, contributes to the process of orthodontic tooth movement. The aim of this study was to determine the effect of differently orthodontic forces on the expression of MMP nine in rat diabetic model. Twenty four male Wistar rats were divided into three groups of control and three groups of treatment streptozotocin-induced diabetes with stratified doses. Application of orthodontic appliance was performed with different forces (10, 20 and 30 grF). Orthodontic appliance was performed on both upper incisors. Immunohisto-chemical (IHC) analysis was used to observe the expression of MMP 9 and HE (Hematoxylen Eosin) staining to observe the number of fibroblasts. Statistical analysis was carried out using t-test and Spearman correlation analysis to determine the difference of MMP nine expression and number of fibroblasts between groups, and determine the correlation of both. The results showed an increased expression of MMP 9 and decreased of fibroblasts number in diabetic rats, along with increasing magnitude of orthodontic forces. The different orthodontic forces given to diabetic rats affect the expression of MMP 9 and the number of fibroblasts, in which the expression of MMP 9 increased along with the increase of orthodontic forces, both at pressure and tension sides.
    URI
    http://repository.unej.ac.id/handle/123456789/62872
    Collections
    • Fakultas Kedokteran Gigi [92]

    UPA-TIK Copyright © 2024  Library University of Jember
    Contact Us | Send Feedback

    Indonesia DSpace Group :

    University of Jember Repository
    IPB University Scientific Repository
    UIN Syarif Hidayatullah Institutional Repository
     

     

    Browse

    All of RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    UPA-TIK Copyright © 2024  Library University of Jember
    Contact Us | Send Feedback

    Indonesia DSpace Group :

    University of Jember Repository
    IPB University Scientific Repository
    UIN Syarif Hidayatullah Institutional Repository