Show simple item record

dc.contributor.authorPutri Aprilina Rahmawati
dc.date.accessioned2013-12-05T01:57:03Z
dc.date.available2013-12-05T01:57:03Z
dc.date.issued2013-12-05
dc.identifier.nimNIM072210101006
dc.identifier.urihttp://repository.unej.ac.id/handle/123456789/4368
dc.description.abstractThe purpose of this research was to optimization mucoadhesive buccal tablets of propanolol hydrochloride using bioadhesive polymer Hidroxy Propyl Methyl Cellulose (HPMC) and Carbopol. Buccal mucoadhesive tablet of propanolol hydrochloride were developed to prolong release time and increase its bioavailability. The tablet were prepared by direct compression technique. The tablets were evaluated for hardness, friability, content uniformity, surface pH, swelling index, mucoadhesive strength, and in vitro drug release profile. The effect of HPMC and carbopol on drug release profile and mucoadhesive strength were investigated. Factorial design method was employed to create the optimum composition of HPMC and carbopol and used to determinate the effect of HPMC and carbopol and their interaction on mucoadhesive strength and dissolution efficiency. The optimum formula which obtain several criteria was investigated with overlay plot. The linier regression analysis and model fitting showed that all this formulation followed Higuchi model, which had highest value of correlation coefficient (r). Optimum compotition based on overlay plot for each tablet is 5 mg - 30 mg of carbopol at 100 mg of HPMC and 20 mg - 100 mg of HPMC at 30 mg carbopol.en_US
dc.language.isootheren_US
dc.relation.ispartofseries072210101006;
dc.subjectbuccal mucoadhesive, propanolol hydrochloride, HPMC, carbopol, factorial designen_US
dc.titleOPTIMASI KOMPOSISI HIDROKSI PROPIL METIL SELULOSA DAN KARBOPOL SEBAGAI SISTEM BUCCAL MUCOADHESIVE TABLET PROPANOLOL HIDROKLORIDAen_US
dc.typeOtheren_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record