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Epi-croomine and croomine from Stemona tuberosa antimalarial drug for inhibiting dihydrofolate reductase (DHFR) activity and their molecular modeling
(2016-12-14)
One of the mechanism actions of antimalarial drugsis by an inhibiting on the enzyme dihydrofolate reductase
(DHFR), an enzyme target antifolate drug. Epi-croomine and croomine
, are alkaloids isolated from
Stemonatuberosa ...