Browsing LSP-Jurnal Ilmiah Dosen by Author "Fajrin, Fifteen Aprila"
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The Activity of Red Ginger Oil in Antioxidant Study In Vitro and Antihyperalgesia Effect in Alloxaninduced Painful Diabetic Neuropathy in Mice
Fajrin, Fifteen Aprila; Imandasari, Nidia; Barki, Tsabit; Sulistyaningrum, Gati; Afifah, Afifah; Kristiningrum, Nia; Puspitasari, Endah; Holidah, Diana (Thai Journal of Pharmaceutical Sciences. 2019, 43 (2): 69-75, 2019-02-28)Background: Red ginger oil (RGO) contains the highest bioconstituent, especially its essential oil which is important for antioxidant, than the other varieties. Chronic diabetic triggers the increase of reactive oxygen ... -
Antihyperalgesia Potency of Zingiber officinale var. Rubrum in Inflammatory and Neuropathy-induced Chronic Pain Condition in Mice
Fajrin, Fifteen Aprila; Purwandhono, Azham; Christianty, Fransisca Maria; Sulistyaningrum, Gati Dwi; Afifah, Afifah; Imandasari, Nidia; Barki, Tsabit (2019-07-25)Chronic inflammation and neuropathic pain are classified into chronic pain. Until now there are so many drugs that have been used for chronic pain but the effectiveness still lower. One of the plants that are commonly ... -
(Efektivitas Agonis GABA terhadap Penurunan Ekspresi Reseptor N-Methyl-D-Aspartate (NMDA) Subunit NR2B pada Mencit Neuropati dengan Metode Partial Sciatic Nerve Ligation (PSNL))
Fajrin, Fifteen Aprila; Khotib, Junaidi; Susilo, Imam (2016-11-01)Nyeri neuropati merupakan nyeri yang disebabkan oleh trauma atau cedera pada saraf. Saat ini, terapi untuk mengatasi nyeri neuropati beralih pada agonis GABA yang menyebabkan kembalinya keseimbangan antara neurotransmitter ... -
Effect of Gabapentin and Baclofen on Histology Study in Neuropathic Pain
Fajrin, Fifteen Aprila (2019-03-13)Neuropathic pain resulted from injury to nerves is often resistant to current treatments and can seriously cause chronic pain if no appropriate treatment is given. This study was designed to prove the effectiveness of ... -
The Effectiveness of GABA Agonist in Decreasing Expression of NR2B Subunit of N-Methyl-D-Aspartate (NMDA) Receptor in Neuropathic Mice by Partial Sciatic Nerve Ligation (PSNL) Method
Fajrin, Fifteen Aprila; Khotib, Junaidi; Susilo, Imam (2019-03-13)Neuropathy pain is a pain that caused by nerves injury. Nowadays, treatment for neuropathic pain change to drugs that works as GABA agonist and cause reimbalance between excitatory and inhibitory neurotransmitter in ... -
Histologi Dorsal Horn dari Spinal Cord Mencit yang Mengalami Nyeri Inflamasi Akibat Induksi CFA (Completed Freud’s Adjuvant) Setelah Pemberian Gabapentin dan Baclofen (Dorsal Horn Histology of Spinal Cord from Mice with CFA (Completed Freud's Adjuvant) Induced Inflammatory Pain After Gabapentin and Baclofen Administration)
Fajrin, Fifteen Aprila; Khotib, Junaidi; Susilo, Imam (2019-03-13)Nyeri merupakan pengalaman yang multidimensional. Umumnya kebanyakan penyakit kronik selalu disertai dengan nyeri. Nyeri kronik dapat disebabkan oleh inflamasi maupun neuropati dengan patofisiologi yang berhubungan ... -
The Improvement of Pain Behavior and Sciatic Nerves Morphology in Mice Model of Painful Diabetic Neuropathy upon Administration of Ginger (Zingiber officinale Roscoe.) Extract and Its Pungent Compound, 6‑Shogaol
Fajrin, Fifteen Aprila; Nurrochmad, Arief; Nugroho, Agung Endro; Susilowati, Rina (Journal of Natural Science, Biology and Medicine, Volume 10 ¦ Issue 2 ¦ July-December 2019, 2019-07-18)Background: 6-Shogaol is one of the bioactive compounds from ginger (Zingiber officinale Roscoe.) that had been widely used in many diseases. This research was aim to investigate the effect of ginger extract and its pungent ... -
Molecular Docking Analysis of Ginger Active Compound on Transient Receptor Potential Cation Channel Subfamily V Member 1 (TRPV1)
Fajrin, Fifteen Aprila; Nugroho, Agung Endro; Nurrochmad, Arief; Susilowati, Rina (2019-07-25)Ginger had been reported to ameliorate Painful Diabetic Neuropathy (PDN) in an animal model. Gingerol and shogaol were active compounds of ginger that potentially act on transient receptor potential cation channel ... -
Optimization of Mice Model of Painful Diabetic Neuropathy (PDN)
Fajrin, Fifteen Aprila; Nurrochmad, Arief; Nugroho, Agung Endro; Susilowati, Rina (2019-07-25)Painful diabetic neuropathy (PDN) is a complication of long-term diabetes mellitus (DM) characterized by hyperalgesia and allodynia. In streptozotocin (STZ)-induced diabetic mice, higher dose of STZ and lengthened ...