| dc.description.abstract | Stenochlaena palustris (Burm.f.) Bedd. (Blechnaceae) or Kelakai is a traditional medicinal plant found in the Indonesian islands of
Borneo and Sumatra. It has been used to treat wound healing, infection, and diabetes. Tis study looked into the free radical scavenging
activity, antiplasmodial activity, toxicity, and antibacterial activity against pathogenic bacteria. Te species’ aerial part was extracted with
methanol, followed by a liquid-liquid extraction against (n-hexane, dichloromethane, and ethyl acetate). Te extracts’ free radical
scavenging activities were determined using DPPH and NO radicals. Te antiplasmodial and toxicity assays were conducted using two
Plasmodium falciparum strains (3D7 and W2) and the brine shrimp lethality test. In addition, antibacterial activity was determined using
the well difusion method. Te results revealed that ethyl acetate depicted potential activities toward the assay. Te ethyl acetate showed
potential free radical scavenging activities with an IC50 value of 51.63±0.46 μg/mL (DPPH) and 60.03±0.65 μg/mL (NO). Te
antiplasmodial activities showed that the ethyl acetate had potential activities among the extracts with an IC50 value of 11.06 ±0.45 μg/
mL. However, all the extracts demonstrated nontoxic toward Artemia salina with LC50>1000 μg/mL. Furthermore, the ethyl acetate
demonstrated intermediate susceptibility against B. cereus ATCC 10876, V. parahaemolyticus ATCC 17802, L. monocytogenes ATCC
7644, and S. Typhimurium ATCC 14028 at a concentration of 500 μg/disc. According to these fndings, the ethyl acetate extract of
S. palustris (Burm.f.) Bedd is a promising source of natural antioxidants and antiplasmodial agents. | en_US |
