| dc.description.abstract | Ovarian failure can be caused by ovariectomy which induces estrogen deficiency. Estrogen
influenced leukocytes as immune and inflammation cells systemically and locally, and leukocytes also
contribute to ovarian function in order to be located in ovaries tissue. The aim of the study was to
investigate the impact of ovarian failure to leukocytes profile in peripheral blood circulation and
gingival fluid. This study was experimental laboratory study approved by the Health and Research
Ethics Committee of Dental Faculty, Gadjah Mada University. The animal models have undergone
ovariectomy which removed their ovarian bilaterally. Blood sampling from retro orbital plexus and
gingival fluid were taken before and 3, 7, 14, 21 and 28th days after ovariectomy procedures. Total
leukocytes counted manually. The result showed that total leukocytes in peripheral blood were higher
than in gingival fluid. Moreover, there were significant differences between leukocytes profile in
peripheral circulation and gingival fluid based on the periods, except in basophils cells counting. The
conclusion was ovarian failure affected leukocytes profile in peripheral blood circulation and gingival
fluid. | en_US |
