| dc.description.abstract | Background and aims. Hyperglycemia in pregnancy was caused by reduced insulin
production that led to tooth germ growth disorder. Thymoquinone could increase insulin
production through pancreatic β-cells regeneration. The purpose of this study was to
determine the effect of thymoquinone to prevent tooth disorder in rat offspring born from
hyperglycemia pregnant rat. Material and method. Wistar rat offspring used in this
research taken from pregnant rat induced hyperglycemia with streptozotocin 40
mg/kgBW divided into four groups. Rat offspring observation had been done on 3rd, 5th
,
and 7th day postnatal. The histological image of first maxillary molar tooth germ stained
with Haematoxilin Eosin and Mallory’s Trichrome. The parameters of rat offspring were
body weight, blood glucose levels, tooth growth stages, tooth dimension width, and tooth
germ enamel matrix. Results. Thymoquinone group had the widest tooth germ dimension
compare to other groups. All rat offspring tooth germs were at the appositioncalcification stage in matrix enamel (pre-enamel). The analysis showed that no statistical
differences between thymoquinone group and metformin group (p>0.05). Conclusions.
Thymoquinone has same function with metformin to prevent tooth disorder in rat
offspring born from pregnant rat induced hyperglycemia. | en_US |
