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dc.contributor.authorFATIMATUZZAHRO, Nadie
dc.contributor.authorPRASETYA, Rendra Chriestedy
dc.contributor.authorANGGARA, Kanwangwang Dwi Nada
dc.date.accessioned2022-03-21T02:36:45Z
dc.date.available2022-03-21T02:36:45Z
dc.date.issued2021-06-09
dc.identifier.govdocKODEPRODI1610101#Kedokteran Gigi
dc.identifier.govdocNIDN0024048203
dc.identifier.govdocNIDN0031058303
dc.identifier.urihttp://repository.unej.ac.id/xmlui/handle/123456789/105953
dc.description.abstractHyperlipidemia is a cause of atherosclerosis, that characterized by an abnormal elevation of cholesterol, especially Low Density Lipoprotein (LDL). It leads to foam cell formation, andcorrelated with the increased level of pro-inflammatory cytokine TNF-α.Inflammatory is assumed to be inhibited by natural ingredients which have antiinflammatory effect. One of the natural product which predicted to have antiinflammatory effect is robusta coffee. This research aimedto investigate the effect of robustacoffee on TNF-α expression in hyperlidemiarat model. Fiveteenmale Wistar rats were randomly divided into 3 groups: Control (K), Hyperlipidemia (H), and coffeerobusta(C). Hyperlipidemia induced by feeding the yolks of duck and pork oil. Infraorbital blood was taken for examination of LDL levels andthe rats were sacrified at 29 day after the treatment. Carotid arteries were then processed histologically. Anova and LSD test results showed levels of LDL in the coffee group were significantly different from the hyperlipidemia group (p < 0.05).Immunohistochemical (IHC) analysis was performed using rabbit anti rat TNF- α polyclonal antibody. Lipid deposition in carotid artery observation within Sudan IV staining.Resultshowed robustacoffee induced lower expression of TNF- α and less lipid deposition in subendotelial layer. StrongTNF-αpositive staining seems on hyperlipidemia group. Robusta coffeedown regulationTNF-α expressionin carotid artery ofhyperlipidemia rat model.en_US
dc.language.isoenen_US
dc.publisherTRENDS IN SCIENCES 2022en_US
dc.subjectRobusta coffee (Coffeacanephora)en_US
dc.subjectLow Density Lipoprotein (LDL)en_US
dc.subjectNF-αen_US
dc.subjectHyperlipidemia rat modelen_US
dc.titleRobusta Coffee (Coffeacanephora) Down Regulation TNF-α Expression in Carotid Artery Endothelial Cell of Hyperlipidemia Rat Modelen_US
dc.typeArticleen_US


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