| dc.description.abstract | he oral route is the main route of drug delivery for various
diseases. Fifty percent of oral administration of drugs is inhibited
due to low drug solubility [1], whereas according to the Noyes
Whitney equation, drug solubility is directly proportional to the
dissolution rate.
Drug dissolution in biological systems is a vital attribute before
systemic absorption. In vitro drug dissolution study is a relatively
fast and inexpensive technique to predict absorption in vivo of a
drug formulation [2]. The dissolution study can reflect differences in
bioavailability due to formulation factors [3]. For drugs with low
solubility, appropriate formulation methods are needed to increase
their solubility.
Meloxicam is a class II Biopharmaceutical Classification System
(BCS) [4], which has very low solubility in water (4.4 g/ml, 25 °C)
[5]. This study used a lipid-based drug delivery system, a self-nano
emulsifying drug delivery system (SNEDDS), to increase meloxicam
solubility. SNEDDS has an advantage in increasing the surface area
leading to increased lipophilic drug dissolution and absorption | en_US |
