| dc.description.abstract | Objective: To compare the level of glutathione (GSH) and oxidized glutathione (GSSG),
the ratio of GSH/GSSG and the concentration of albumin in plasma of patients with
complicated and un-complicated falciparum malaria.
Methods: This research was a cross sectional study using comparison analysis with the
plasma GSH and GSSG, the ratio of plasma GSH/GSSG and the concentration of plasma
albumin as variables. The complicated malaria patients were obtained from Dr. Saiful
Anwar Hospital Malang, whereas uncomplicated malaria patients were obtained from the
Regency of Pleihari South Kalimantan. Plasma GSH and GSSG levels were determined
by the spectrophotometer at the wave length of 412 nm, whereas the concentration of
albumin was determined by bromocresol green method in the pH of 4.1.
Results: There were no significant differences between the level of plasma GSH and GSSG
in complicated and uncomplicated malaria patients, as well as the ratio of plasma GSH/
GSSG in the two groups (P = 0.373; P = 0.538; and P = 0.615, respectively, independent ttest). In contrast, the plasma albumin concentration in complicated malaria patients were
significantly higher than uncomplicated malaria patients (P = 0.000, Mann Whitney U test).
Conclusions: It can be concluded that the average of plasma GSH and GSSG level, also
plasma GSH/GSSG ratio in complicated malaria are not different from uncomplicated malaria. Although plasma concentration of albumin in both groups is below the normal range,
there is an increase in complicated malaria that might be as compensation of oxidative stress | en_US |
