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dc.contributor.authorPERTIWI, Adinda Kusuma
dc.contributor.authorHABIBURROHMAN, Muhammad
dc.contributor.authorDEBBY, Yoshinta
dc.contributor.authorTRIATMOKO, Bawon
dc.contributor.authorNUGRAHA, Ari Satia
dc.date.accessioned2021-05-21T01:14:57Z
dc.date.available2021-05-21T01:14:57Z
dc.date.issued2021-03-09
dc.identifier.urihttp://repository.unej.ac.id/handle/123456789/104709
dc.description.abstractThe anti-malarial potency of Indonesian medicinal plants was evaluated through computational study. From 43 Indonesian medicinal plants, 238 previously reported compounds were carefully docked into HAP (histo-aspartic protease) with codename 3FNT in which the enzyme plays an important catalytic role in Plasmodium falciparum innate metabolism. Exhaustive docking experiments produced 6 best hits molecules including AM210 (4-hydroxy- 3-methoxy strychnine), AM213 (protostrychnine), and AM216 (pseudostrychnine) which have less free energy compared to HAP native ligand, 1,2-ethanediol. This study revealed the potency of Strychnos nux-vomica L. as a source for antimalaria and support its traditional claimsen_US
dc.language.isoenen_US
dc.publisherThe 3rd International Conference on Life Sciences and Biotechnologyen_US
dc.subjectHAP inhibitoren_US
dc.subjectMolecular dockingen_US
dc.subjectAntimalariaen_US
dc.subjectStriychnos nux-vomicaen_US
dc.titleEthnopharmacology and Computer-Aided Tandem Protocol to Search for Antimalarial Agents From Indonesian Medicinal Plants: Hap Inhibitoren_US
dc.typeArticleen_US
dc.identifier.kodeprodiKODEPRODI2210101#Farmasi
dc.identifier.nidnNIDN0029018202
dc.identifier.nidnNIDN0021077803


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