| dc.description.abstract | Annona species have been a valuable source of anti-infective and anticancer agents. However,
only limited evaluations of their alkaloids have been carried out. This review collates and evaluates
the biological data from extracts and purified isolates for their anti-infective and anti-cancer activities.
An isoquinoline backbone is a major structural alkaloid moiety of the Annona genus, and more than
83 alkaloids have been isolated from this genus alone. Crude extracts of Annona genus are reported
with moderate activities against Plasmodium falciparum showing larvicidal activities. However, no
pure compounds from the Annona genus were tested against the parasite. The methanol extract of
Annona muricata showed apparent antimicrobial activities. The isolated alkaloids from this genus
including liriodenine, anonaine, asimilobine showed sensitivity against Staphylococcus epidermidis.
Other alkaloids such as (+)-Xylopine and isocoreximine indicated significant anti-cancer activity
against A549 and K-562 cell lines, respectively. This review revealed that the alkaloids from Annona
genus are rich in structural diversity and pharmacological activities. Further exploration of this genus
and their alkaloids has potential for developing novel anti-infective and anticancer drugs | en_US |
