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    In Silico Study of Histo-Aspartic Protease (HAP) Inhibitor From Indonesian Medicinal Plants: Anti-Malarial Discovery

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    Farmasi_PROCEDING_ARI SATIA_In Silico Study of Histo-aspartic Protease (HAP) Inhibitor from Indonesian.pdf (1017.Kb)
    Date
    2021-03-07
    Author
    RANI, Dinar Mutia
    HABIBURROHMAN, Muhammad
    DEBBY, Yoshinta
    TRIATMOKO, Bawon
    NUGRAHA, Ari Satia
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    Abstract
    Malaria is an infectious disease caused by Plasmodium sp with the highest clinical incidence of 12.07% in Indonesia. New anti-malaria compounds are needed to replace antimalarial drugs that are already resistant nowadays. One of the efforts to find a new anti-malaria drug is through research on traditional medicinal plants used by Indonesian tribes from the ethnopharmacology database. In silico studies provide saving solutions in the process of computer-aided drug design. Histo-aspartic protease (HAP) is essential for the growth of Plasmodium falciparum and has been validated as an antimalarial drug target. Therefore, molecular docking was used to provide new insights into the development of drugs by targeting HAP protease. There are 238 compounds from 43 medicinal plants used as targeting ligand in this study prepared by Autodock Vina for an automated docking tool. The comprehensive docking protocol was valid showed by the RMSD value of 1,275 Å. The result obtained that AM50 (borrasosides A) from Borassus flabellifer was found to have the least affinity score of -10.1 kcal/mol higher compared to the native ligand. In conclusion, we are assuming that the mechanism of borrasosides A compound might get involved with HAP. Further protocols are required to prove the HAP inhibition towards Plasmodium falciparum
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    http://repository.unej.ac.id/handle/123456789/104408
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    • LSP-Conference Proceeding [1877]

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    UPA-TIK Copyright © 2024  Library University of Jember
    Contact Us | Send Feedback

    Indonesia DSpace Group :

    University of Jember Repository
    IPB University Scientific Repository
    UIN Syarif Hidayatullah Institutional Repository