| dc.description.abstract | Ring-opening reaction of cyclic pentose sugar derivatives of 2,3,4-Tri-O-benzyl- D-xylopyranose to
derivatives of acyclic 2,3,4-Tri-O-benzyl-D-xylose-Dipropyl dithioacetal been done and optimized.
The reaction was performed using a precursor propanathiol with concentrated HCl. Optimization of
reaction conditions was conducted by varying propanathiol concentration, reaction time and
optimization of the reaction temperature which the product ioslation conducted using a variety of
solvents. The results of this reaction was obtained 2,3,4-Tri-O-benzyl- D-xylose-Dipropyl
dithioacetal with the highest randemen (97%), better than the previous reaction through propanathiol
excessive concentration, reaction time of 2 hours and the temperature of the reaction at room
temperature. Product Isolations using solvent dikloromathane more effective than the use of other
organic solvents. Purification of reaction products is done through a column chromatography using a
solvent mixture of 20% ethyl acetate-hexane. | en_US |
