| dc.description.abstract | Tuberculosis is a chronic infectious disease
caused by Mycobacterium tuberculosis. Toll-Like
Receptor-2 (TLR-2) signaling plays a role in the
body's defense system against Mycobacterium
tuberculosis. Daun Ungu (Graptophyllum pictum L.
Griff) is a traditional herbal plants which has medicinal
properties for infectious and inflammatory diseases. This study aimed at analyzing the expression ofTLR-
2 of mice with the administration of methanol extract of Daun Ungu (Graptophyllum pictum L. Griff). The
method used was an experimental laboratory, thirty
male mice aged 8-12 weeks were randomly allocated
into 5 groups; 2 control groups (KO, K 1 ), 3 treatment
groups (PI, P2, P3 ). KI, PI, P2 and P3 were infected
using Mycobacterium tuberculosis at a dose of 108 ml
tuberculosis. Macrophages are professional phagocytic
cells with main function to destroy inununogen and as
and left for 4 weeks. At the fifth week groups PI, P2
and P3 were administered with methanol extract
of
Graptophyllum pictum L. Griff (EMDU) at a dose
I, 703 mg, 3 .406 mg, 6. 812 mg. The administration of
0.2 ml was
conducted every other day for 2 weeks.
Examination of the expression of TLR-2 was carried
out using immunohistochemical techniques. The data
were analyzed using ANOV A and correlation analysis.
The results showed that the EMDU in mice infected
with Mycobacteriwn
tuberculosis
by imununohistochemical technique was succeed that the
EMDU could increase the expression of TLR-2. The
results of the correlation test showed a positive
correlation between dose EMDU with TLR-2
expression. The conclusion of this study is that the
EMDU can increase expression ofTLR-2. | en_US |
