|dc.description.abstract||Introduction: Based on epidemiological data, the periodontitis prevalence in
Indonesia reached 96.58%. Periodontitis is a periodontal disease caused by
specific microorganisms causing attachment loss, alveolar bone resorption,
and periodontal pocket. The pocket which is more than 6 mm couldn’t be
carried out using standard care. Therefore bone grafting is needed to fix the
bone defect. Cowhide Gelatin nanoparticle (GNPs) combined with TitaniumPrepared
titanium-prepared platelet-rich fibrin (T-PRF) as an innovation in the
healing of periodontitis defects.
Literature review: Cowhide GNPs are the main ingredients for the bone
replacement, which are nano-sized, biocompatible, bioactive, osteoconductive,
non-toxic, and have a porous structure that supports the drug-delivery process.
T-PRF contains platelets, fibrin, growth factors that can stimulate bone
Discussion: GNPs support the attachment and proliferation of osteoblast cells
and the formation of mineralized bone matrix. The contents of T-PRF, which
are fibrin, platelets, and growth factors, one of TGF-β1 will produce bone
formation and periodontal healing in the large number. Moreover, T-PRF has
leukocyte-fibrin, which may give an antibacterial effect. Thus, GNPs combined
with T-PRF have more potent properties that support each other in carrying out
their functions to stimulate the healing process.
Conclusion: The combination of cowhide gelatin nanoparticles (GNPs) and
titanium-prepared platelet-rich fibrin (T-PRF) has the potential to be effective in
bone regeneration in periodontitis defects.||en_US