| dc.description.abstract | Ginger was reported to have a suppressive effect on pain in patients with Painful Diabetic
Neuropathy (PDN). Our latest study revealed that 6-shogaol, one of the ginger components, had
the best affinity in the Transient Receptor Potential Vanilloid 1 (TRPV1), a key receptor in PDN).
Paradol, which obtained from gingerol and shogaol metabolism, also had potent activities in
several diseases, compared to the other derivatives of gingerol and shogaol. However, shogaol and
paradol is very similar in chemical structure with only different in one double bond in 4-5 position.
Until now there is no explanation about paradol mechanism in TRPV1. Based on this, our study
was designed to predict the activity of 6-paradol and its derivatives to TRPV1 as target receptor in
PDN using in-silico model. 2-paradol, 4-paradol, 6-paradol, 8-paradol and 10-paradol were used as
ligands. Capsaisin, the agonist of TRPV1, was used as a native ligand in this study. TRPV1 was
obtained from protein data bank (PDB). Ligand bond prediction and affinity was performed using
Molegro Virtual Docker. The results showed 2-paradol, 4-paradol, 6-paradol, 8-paradol and 10paradol
had
good
affinity
against
TRPV1.
These
result
indicated
that
6-paradol
and
the
derivatives
had
potential
as
a
drug
compound
for
PDN
therapy. | en_US |
