| dc.description.abstract | Context: The side effect of Ketoprofen in oral administration is gastrointestinal
disorders and kidney failure. The transdermal route can solve this problem, and
need penetration enhancer to increase the penetration into the skin. Aims: The
aims of this study were to determine the effect of glycerin on the penetration of a
ketoprofen patch. Settings and Design: Four formulas of solid ketoprofen–patch
preparation with different amounts of glycerin as a penetration enhancer are tested
statistically to observe the difference of rat skin penetration. Methods and
Material: Ketoprofen make to be a solid dispersion, then evaluated of
homogeneity and FTIR. Solid dispersion make to be a patch, then evaluated of
organoleptic, weight homogeneity, thickness, folding endurance, assay, pH,
moisture content, FTIR, a rate of in vitro penetration, and one–way ANOVA
analysis. Statistical analysis used: One Way ANOVA Analysis. Results:
Glycerin can increase the flux of ketoprofen patch and has different significant in a
test with one-way ANOVA analysis. Conclusions: From this research can be
concluded that the addition of glycerin in the formula patch can increase the rate of
penetration of ketoprofen patch is described by the value of flux. The higher
concentration of glycerin in the patch can increase the value of flux produced.
Mechanism of glycerin as penetration enhancers by increasing the solubility of
active ingredients and hydrate the stratum corneum. Glycerin also increases the
value of patches for hygroscopic moisture. | en_US |
