Polysaccharide Krestin Activity From Coriolus Versicolor Extract Against Phagocytosis Ability on Mice Infected by Staphylococcus Aureus
Date
2021-04-01Author
SAVIRA, Nadyatul Ilma Indah
WAHYUNINGSIH, Sri Puji Astusik
RAHMAWATI, Dewi
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Staphylococcus aureus is an opportunistic pathogen and cause of nosocomial infection, which
has leucocidin and can reduce immunity. Because of antibiotic resistance, immunomodulator is
an alternative treatment for S. aureus infection. Polysaccharide krestin (PSK) from Coriolus
versicolor extract contains active β-glucan that triggers immune responses' effectiveness
including phagocytosis. This research aimed to know the activity of PSK against phagocytosis
ability on mice infected by S. aureus. There were six treatment groups. 100 mg/kg BW PSK was
given to the mice strain Balb/C by gavage. S. aureus was infected once every two weeks.
Phagocytosis ability consisted of phagocytic activity and capacity, counted on slide smears of
mice intraperitoneal fluid. The results showed that PSK increased phagocytic activity in the group
giving PSK after infection. Furthermore, the most effective giving PSK on phagocytic capacity
was before and after infection. Based on this research, PSK increased immunity by phagocytosis
ability and can be useful as an immunomodulator
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- LSP-Jurnal Ilmiah Dosen [7287]