Please use this identifier to cite or link to this item: https://repository.unej.ac.id/xmlui/handle/123456789/99479
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dc.contributor.authorSUSILO, Imam-
dc.contributor.authorDEVI, Anita-
dc.contributor.authorPURWANDHONO, Azham-
dc.contributor.authorWARSITO, Sunaryo Hadi-
dc.date.accessioned2020-06-30T19:24:32Z-
dc.date.available2020-06-30T19:24:32Z-
dc.date.issued2017-06-07-
dc.identifier.urihttp://repository.unej.ac.id/handle/123456789/99479-
dc.description.abstractWound healing is a physiological process that occurs progressively through overlapping phases. Tissue oxygenation is an important part of the complex regulation for wound healing. Hyperbaric Oxygen (HBO) therapy is a method of increasing oxygen delivery to tissues. The therapy improves tissue oxygenation and stimulates the formation of H2O2 as a secondary messenger for Tumour Necrosis Factor alpha (TNF α), e-NOS, VEGF and Nuclear Factor Kappa Beta phosphorylation (NF-Kb) which play an important role in the rapid transcription of a wide variety of genes in response to extracellular stimuli. This study aims to determine the effects of Hyperbaric Oxygen therapy in enhancing the expressions of e-NOS, TNF-α, VEGF and wound healing. This study is an animal study with a ‘randomized control group of pre-test and post test design’ on 28 Wistar rats. Randomly, the rats were divided into 4 groups with 7 rats in each group. The HBO treatment group 1 received 5 sessions of HBO 2.4 ATA in 3x30 minutes; the HBO treatment group 2 received 10 sessions of HBO 2.4 ATA in 3x30 minutes; and each of the control groups were without HBO. Each of the 28 male rats were given a full thickness excisional wound of 1x1cm. Examinations of e-NOS, TNF-α, VEGF expressions and wound healing were performed on day-0 (pre-HBO) and day-5 HBO or on day-0 (pre-HBO) and day-10 HBO.The resultsshowthat the Hyperbaric Oxygen therapy can improve e-NOS (p=0.02), TNF-α (p= 0.02), VEGF expression (p=0.02) and wound healing (p=0.002) significantly in the provision of HBO 2.4 ATA for 3x30 minutes in 5 sessions over 5 consecutive days. While the 10 sessions of HBO 2.4 ATA for 3x30 minutes over 10 consecutive days only increase e-NOS (p=0.02), TNF-α (p=0.04), VEGF expression significantly (p=0.03) but do not improve wound healing significantly (p=0.3) compared with no HBO. The study concludes that HBO can improve the expressions of e-NOS, TNF-α, VEGF and wound healing in the provision of HBO 2.4 ATA for 3x30 minutes in 5 sessions, while the 10 sessions of HBO 2.4 ATA for 3x30 minutes only increase e-NOS, TNF-α, VEGF expression but do not improve wound healing.en_US
dc.language.isoenen_US
dc.publisherIOP Conf. Series: Journal of Physics: Conf. Series 853 (2017) 012030en_US
dc.subjecthyperbaric oxygen therapyen_US
dc.subjectexpressions of e-NOS, TNF-α and VEGFen_US
dc.subjectwound healingen_US
dc.titleEffects of Hyperbaric Oxygen Therapy in Enhancing Expressions of e-NOS, TNF-α and VEGF in Wound Healingen_US
dc.typeArticleen_US
dc.identifier.kodeprodiKODEPRODI2010101#Pendidikan Dokter-
dc.identifier.nidnNIDN0018058104-
Appears in Collections:LSP-Jurnal Ilmiah Dosen

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