Antipyretic Effects of Dried Earthworm (Pheretima Javanica K.) in Male White Rat (Rattus Norvegicus) with Typhoid Fever

Abstract

Typhoid fever is a disease caused by Salmonella typhi bacterial infection, The symptoms commonly caused by this disease are usually fever, dizziness, nauseaand even diarrhea. Using Chloramphenicol as a medicine has been experienced resistancefor the last few years and has side effects. The aim of this research is to produce an alternative medicine of typhoid fever without side effects from dried earthworm (Pheretima javanica K.) in male white rats (Rattus norvegicus L.). This research is an experimental study, with 2 control group and 4 treatments group of each 10 white rats. The 4 tests are consist of Widal Test, body weight measurement, body temperature measurement and feces test. Widal test, feces test and body weight measurement were analyzed descriptively, while body temperature measurement was analyzed by using ANOVA test and continued with Duncan test with confidence rate at 95%. The analyzed result got probably result p = 0,000 (p < 0,05) means that dried earthworm has a significant effect on the reduction of typhoid fever on male white rats. The most optimal dose was gained from treatment 2 (dried earthworm induction with dose 0,8 gs/0,2 Kg of weight) which had similar value with the positive control with chloramphenicol induction.