Efek Nefroprotektif Ekstrak Bawang Kucai (Allium tuberosum) Terhadap Kadar Blood Urea Nitrogen (BUN) dan Kreatinin Tikus Wistar yang Diinduksi Doxorubicin (Nephroprotective Effect of Garlic Chives (Allium tuberosum) on BUN and Creatinine Levels of Wistar Rats Induced By Doxorubicin)

Abstract

Cancer is the most leading disease that cause of death. Doxorubicin chemotherapy is often used in cancer treatment, because of its effectiveness. Although doxorubicin

has a positive effect for killing cancer cell, doxorubicin has many side effects, one of which doxorubicin can cause kidney damage through the process of interstitial

fibrosis. Utilization garlic chives ex-tract as co chemotherapy to reduce renal damage induced by doxorubicin is a prospective opportunities. This study aimed to analyze the effect of garlic chives extract as a nephropro-tective on levels of BUN and creatinine of wistar rats induced by doxorubicin. The research method was quasi experimental design with post test only randomized controlled group. The results showed that extracts of garlic chives can reduce levels of BUN and creatinine

(p <0.05) in the group that only induced by doxorubicin. In conclusion, extract

of garlic chives has nephroprotecive effects on wistar rats which were in- duced by doxorubicin.