Please use this identifier to cite or link to this item: https://repository.unej.ac.id/xmlui/handle/123456789/86345
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRachmawati, Dessy-
dc.contributor.authorAlsalem, Inas W.A-
dc.contributor.authorBontkes, Hetty J.-
dc.contributor.authorVerstege, Marleen I.-
dc.contributor.authorGibbs, Sue-
dc.contributor.authorBlomberg, B. Mary E. von-
dc.contributor.authorScheper, Rik J.-
dc.contributor.authorHoogstraten, Ingrid M. W. van-
dc.date.accessioned2018-07-24T02:48:21Z-
dc.date.available2018-07-24T02:48:21Z-
dc.date.issued2018-07-24-
dc.identifier.issn0887-2333-
dc.identifier.urihttp://repository.unej.ac.id/handle/123456789/86345-
dc.descriptionToxicology in Vitro Journal 29 (2015) 363–369en_US
dc.description.abstractNickel, cobalt and palladium ions can induce an innate immune response by triggering Toll-like receptor (TLR)-4 which is present on dendritic cells (DC). Here we studied mechanisms of action for DC immunotoxicity to gold and mercury. Next to gold (Na 3 Au (S 2 O 3 ) 2 2H 2 O) and mercury (HgCl ) was included as a positive control. MoDC activation was assessed by release of the pro-inflammatory mediator IL-8. Also PBMC were studied, and THP-1 cells were used as a substitution for DC for evaluation of cytokines and chemokines, as well as phenotypic, alterations in response to gold and mercury. Our results showed that both Na 3 Au (S 2 O 3 ) 2 2H 2 O and HgCl induce substantial release of IL-8, but not IL6, CCL2 or IL-10, from MoDc, PBMC, or THP-1 cells. Also gold and, to a lesser extent mercury, caused modest dendritic cell maturation as detected by increased membrane expression of CD40 and CD80. Both metals thus show innate immune response capacities, although to a lower extent than reported earlier for NiCl 2 , CoCl 2 and Na 2 [PdCl 4 2 ]. Importantly, the gold-induced response could be ascribed to TLR3 rather than TLR4 triggering, whereas the nature of the innate mercury response remains to be clarified. In conclusion both gold and mercury can induce innate immune responses, which for gold could be ascribed to TLR3 dependent signalling. These responses are likely to contribute to adaptive immune responses to these metals, as reflected by skin and mucosal allergies.en_US
dc.language.isoenen_US
dc.subjectTLR3en_US
dc.subjectContact allergyen_US
dc.subjectGolden_US
dc.subjectMercuryen_US
dc.subjectDendritic cellsen_US
dc.subjectInnate immunityen_US
dc.titleInnate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury)en_US
dc.typeArticleen_US
Appears in Collections:LSP-Jurnal Ilmiah Dosen

Files in This Item:
File Description SizeFormat 
F. KG_Jurnal_Dessy R_Innate stimulatory capacity.pdf2.92 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.