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dc.contributor.authorRachmawati, Dessy-
dc.contributor.authorMuris, Joris-
dc.contributor.authorScheper, Rik J.-
dc.contributor.authorRustemeyer, Thomas-
dc.contributor.authorKleverlaan, Cornelis J.-
dc.contributor.authorFeilzer, Albert J.-
dc.contributor.authorBlomberg, B. Mary E. von-
dc.contributor.authorHoogstraten, Ingrid M. W. van-
dc.date.accessioned2018-07-24T02:38:58Z-
dc.date.available2018-07-24T02:38:58Z-
dc.date.issued2018-07-24-
dc.identifier.issn0891-6934-
dc.identifier.urihttp://repository.unej.ac.id/handle/123456789/86343-
dc.descriptionAutoimmunity Journal, Vol 48, Issue 7, 2015en_US
dc.description.abstractAim: The role of metal exposure in the development of autoimmune disease (AID) is still controversial. Here, we studied the relationship between oral metal exposure, metal allergy and autoimmunity. Methods: A mixed population (n ¼78) of non-allergic volunteers, metal-allergic patients and patients with oral problems putatively due to metal alloys was evaluated for oral Ni, Pd, Au and Hg exposure and skin hypersensitivity. Clinical autoimmune parameters were based on medical histories; additionally, serum levels of the four most common autoantibodies were measured. Results: Skin hypersensitivity, as seen mainly for Ni and/or Pd, was not positively associated with autoimmune parameters. In contrast, metal hypersensitive individuals showed an extremely low frequency of thyroid autoantibodies (3% vs 20% in nonhypersensitive controls). Next, the relation between metal exposure and autoimmunity was evaluated in individuals 435 years (n ¼58), since from that age on metal exposure had plateaued and was not correlated with age. In this subgroup, oral Ni exposure was associated (p50.01) with self-reported AID, irrespective of autoantibody levels. These unexpected findings warrant further confirmation in a larger test group. Of note, oral Pd, Au or Hg contacts were not associated with any of the clinical or serological autoimmune phenomena tested. Conclusion: The results of this study support the view that development of metal contact allergies may prevent autoimmune activation, and, second, that oral exposure to Pd, Au or Hg does not facilitate the development of AID.en_US
dc.language.isoenen_US
dc.subjectAmalgamen_US
dc.subjectautoimmunityen_US
dc.subjectallergyen_US
dc.subjectgolden_US
dc.subjectnickelen_US
dc.subjectoral metal exposureen_US
dc.subjectpalladiumen_US
dc.titleContinuing the quest for autoimmunity due to oral metal exposureen_US
dc.typeArticleen_US
Appears in Collections:LSP-Jurnal Ilmiah Dosen

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